The effect of prenatal fish-oil and folic acid on cognition in 6.5 yr old offspring

In this randomized controlled trial, the long-term effect of omega-3 and 5-methyltetrahydrofolate (5-MTHF) supplement during pregnancy was studied to see if there was an effect on the cognitive function of their children at 6.5 yrs of age. This was performed in 3 European centers where women were assigned to one of four intervention groups. In each group, they received their treatment from the 20th week of gestation until delivery.
Group 1: 500mg DHA + 150mg EPA
Group 2: 400µg 5-MTHF (folic acid)
Group 3: 500mg DHA+ 150mg EPA + 400µg 5-MTHF
Group 4: Placebo
Higher maternal erythrocyte DHA levels at delivery was linked to a higher mental and Processing Score in the offspring. Although there was no observable significant effect of supplement on cognitive function in children, maternal DHA status was still significantly related to alter cognitive development in the offspring.

Fish oil-Natural(Tuna) which contains DHA and EPA are present in PM Procare (Pregnancy & Breastfeeding formulation, 130mg DHA and 30mg EPA) and PM Bright Kids (for children’s eye, neural and immune health,260mg DHA, 60mg EPA).

Folic acid can be found in PM Procare (Pregnancy & Breastfeeding formula and AB Extra bone-care + (comprehensive calcium supplement).

Campoy, C., et al., Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. Am J Clin Nutr, 2011.