The link between maternal vitamin D intake and Type 1 diabetes in the offspring

Vitamin D has been postulated to be involved in immunity as the enzyme responsible for the conversion of inactive vitamin D to its active form is found in many immune cells (macrophages, dendritic cells, B and T cells). It is also hypothesized to be protective in autoimmunity, a condition which T1DM falls under.

This case-control study involved 29,072 women whose offspring either developed type 1 diabetes (T1DM) before 15 years of age, or whose offspring did not develop T1DM (control group). The serum levels of 25(OH)D was lower in the women whose children had T1DM compared to the control group. The odds of developing T1DM was two-fold higher in children born to mothers at the bottom quartile of 25(OH)D during pregnancy than compared to women in the highest quartile. A linear trend in serum 25(OH)D level and incidence of T1DM was seen.

Vitamin D3 (cholecalciferol) is present in AB Extra Bone-care+ (comprehensive calcium supplement) and PM Next G Cal (Strengthen bones, tissues and teeth).

Sorensen, I.M., et al., Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring. Diabetes, 2011.