Vitamin D and fetal growth in the context of pre-eclampsia

In this case-control study, 56 women with early-onset, severe pre-eclampsia were studied to see the correlation between serum 25(OH)D (vitamin D) and small-for-gestational age infants (SGA). The cause of pre-eclampsia is still largely elusive but the placenta is strongly implicated in the pathogenesis of this disease. The only cure for severe eclampsia is to remove the fetus, be it term or premature. The authors found that the 25(OH)D levels were significantly lower (16.8ng/mL) in mothers who gave birth to SGA infants than those with normal fetal growth (25(OH)D: 25.3ng/mL). There was a significant correlation between vitamin D levels and fetal growth. Thus vitamin D can impact on fetal growth, possibly through the placenta in pre-eclampsia. The placenta also has enzymes to convert inactive vitamin D to its active form for local or paracrine use. Vitamin D may induce the expression of vascular endothelial growth factor which promotes angiogenesis. This factor is decreased in preeclampsia.

Vitamin D3 (cholecalciferol) is present in AB Extra Bone-care+ (comprehensive calcium supplement) and PM Next G Cal(Strengthen bones, tissues and teeth).

Robinson, C.J., et al., Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol, 2011. 204(6): p. 556 e1-4.